Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependent Increase of mRNA Levels of 5a-Reductase Type 2 in Contrast to Decrease of Androgen Receptor in the Pubertal Ventral Prostate
نویسندگان
چکیده
*Environmental Health Sciences Division, National Institute for Environmental Studies, 16–2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan; †CREST-JST, Kawaguchi, Saitama 332-0012, Japan; ‡Department of Hygienic Chemistry, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo 162-0826, Japan; and §Regional Environment Division, National Institute for Environmental Studies, 16–2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan
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Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interferes with normal development of the male reproductive system in rats and mice. We examined the effects of TCDD on the initial development of the urogenital system (urethra, prostate, and seminal vesicles) in male rat fetuses on gestation day (GD) 20. The number of prostatic buds and size of prostate glands as well as seminal ves...
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